反应详情

To a solution of (1-benzyl-piperidin-4-ylidene)-cyano-acetic acid ethyl ester (112.9 g, 0.40 mol) in EtOH (500 ml) and H2O (100 ml), potassium cyanide (64.6 g, 0.99 mol) is added at ambient temperature. The reaction mixture is stirred at 65 C.° for 24 h. After removal of EtOH, H2O is added to the residue. The waster phase is extracted with diethyl ether. The combined extracts are washed with H2O and brine, dried over sodium sulfate and evaporated down to give 77.7 g of 1-benzyl-4-cyanomethyl-piperidine-4-carbonitrile.

1. customAfter removal of EtOH, H2O
2. additionis added to the residue
3. extractionThe waster phase is extracted with diethyl ether
4. washThe combined extracts are washed with H2O and brine
5. dry with materialdried over sodium sulfate
6. customevaporated down