Trifluoroacetic acid → HCID 68981335, compound

HRID 491479Notes

Reaction equation

HRID 491479 reaction equation
C(OC([N:8]1[CH2:44][CH2:43][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][N:13]([CH2:22][C:23]3[N:33]([CH2:34][CH2:35][CH:36]4[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]4)[C:26]4[N:27]=[C:28]([C:31]#[N:32])[N:29]=[CH:30][C:25]=4[CH:24]=3)[C:12]2=[O:42])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:45][C:46]([F:51])([F:50])[C:47]([OH:49])=[O:48]>ClCCl>[F:45][C:46]([F:51])([F:50])[C:47]([OH:49])=[O:48].[CH:36]1([CH2:35][CH2:34][N:33]2[C:26]3[N:27]=[C:28]([C:31]#[N:32])[N:29]=[CH:30][C:25]=3[CH:24]=[C:23]2[CH2:22][N:13]2[C:12](=[O:42])[C:11]3([CH2:43][CH2:44][NH:8][CH2:9][CH2:10]3)[N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14]2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10393766HCID 10393766, compound

Product 1

HCID 68981335HCID 68981335, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-[2-cyano-7-(2-cyclohexyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethyl]4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (340 mg, 0.56 mmol) in dichloromethane (5 ml), trifluoroacetic acid (5 ml) is added. After stirring for 1 h at room temperature, solvent is evaporated down to give 7-(2-cyclohexyl-ethyl)-6-(4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile trifluoroacetic acid salt in quant yield.

Workup

  1. customsolvent is evaporated down

Sources & evidence

ORD record
ord-16cb316a8d7b47fb968c4f2bd5c77f38
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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