Trifluoroacetic acid → 7-(2-Cyclohexyl-ethyl)-6-(2,8-diaza-spiro[4.5]dec-8-ylmethyl)-7h-pyrrolo[2,3-d]pyrimidine-2-carbonitrile trifluoroacetic acid salt

HRID 491482Notes

Reaction equation

HRID 491482 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C:10]2([CH2:17][CH2:16][N:15]([CH2:18][C:19]3[N:29]([CH2:30][CH2:31][CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)[C:22]4[N:23]=[C:24]([C:27]#[N:28])[N:25]=[CH:26][C:21]=4[CH:20]=3)[CH2:14][CH2:13]2)[CH2:9]1)=O)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[CH:32]1([CH2:31][CH2:30][N:29]2[C:22]3[N:23]=[C:24]([C:27]#[N:28])[N:25]=[CH:26][C:21]=3[CH:20]=[C:19]2[CH2:18][N:15]2[CH2:14][CH2:13][C:10]3([CH2:9][NH:8][CH2:12][CH2:11]3)[CH2:17][CH2:16]2)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 689806158-[2-cyano-7-(2-cyclohexyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethyl]-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

Product 1

HCID 689792207-(2-Cyclohexyl-ethyl)-6-(2,8-diaza-spiro[4.5]dec-8-ylmethyl)-7h-pyrrolo[2,3-d]pyrimidine-2-carbonitrile trifluoroacetic acid salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 8-[2-cyano-7-(2-cyclohexyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethyl]-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (300 mg, 0.59 mmol) in dichloromethane (5 ml), trifluoroacetic acid (3 ml) is added. After stirring for 1.5 h at room temperature, solvent is evaporated down to give 7-(2-cyclohexyl-ethyl)-6-(2,8-diaza-spiro[4.5]dec-8-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile trifluoroacetic acid salt in quant yield.

Workup

  1. customsolvent is evaporated down

Sources & evidence

ORD record
ord-f92f7b48a5a44de990361b4b84e095bf
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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