HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1H-Indole-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Indole-3-Carboxylic Acid | HCID 69867 | — |
| Product | 1H-Indole-3-carbonyl chloride | HCID 12380278 | — |
Reaction Steps
Indole 3-carboxylic acid, (2.0 g) was dissolved in 5 ml of SOCl2. The mixture was heated to reflux for 30 minutes. Removal of excess of SOCl2 under vacuum provided intermediate 9, indole 3-carbonyl chloride, which was carried to the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531552B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-3b62beb507e34530af5bba95bc121ff6 |
| Source note | uspto-grants-2009_05 |