反应详情

A mixture of 4-(4-Aminomethyl-phenoxy)-phenol (0.10 g, 0.47 mmol), MMP-resin (polystyrene bound N-methylmorpholine-type base, 0.30 g, 1.04 mmol) and 1.9 mL of acetonitrile was treated with propionyl chloride (0.086 mL, 1.0 mmol) and shaken for 24 hours at room temperature. After filtration of the resin, the filtrate was diluted with 2 mL of methanol and was treated with 2 mL of 1M lithium hydroxide (LiOH) in water. The mixture was shaken for 24 hours at room temperature, treated with Amberlite IRP-64® resin until neutral, filtered and concentrated in vacuo, affording N-[4-(4-Hydroxy-phenoxy)-benzyl]-propionamide. MS (m/z): 272.2 [M+H]+.

1. filtrationAfter filtration of the resin
2. additionthe filtrate was diluted with 2 mL of methanol
3. additionwas treated with 2 mL of 1M lithium hydroxide (LiOH) in water
4. stirringThe mixture was shaken for 24 hours at room temperature
5. additiontreated with Amberlite IRP-64® resin until neutral,
6. filtrationfiltered
7. concentrationconcentrated in vacuo