反应详情

温度

70 °C

To 3-oxo-3-pyridin-4-yl-propionitrile (10.0 g, 45 mmol) in 50 mL of acetic acid was added hydrazine monohydrate (1.59 g, 50 mmol) and the solution was heated to 70° C. overnight. The resulting white precipitate was collected and washed with diethyl ether and dried in vacuum to afford: 5.1 g (56% yield) of the title compound as an acetate salt. 1H NMR d6-DMSO: 10.90-10.60 (1H, vbs) 8.60-8.59 (2H, d), 7.71-7.70 (2H, d), 7.15-6.90 (1H, br s), 2.03 (3H, s), 1.87 (3H, s). FIA MS: MH+203.1, M−201.2.

1. customThe resulting white precipitate was collected
2. washwashed with diethyl ether
3. customdried in vacuum
4. customto afford