Potassium Hydroxide → HCID 66849176, compound

HRID 491576Notes

Reaction equation

HRID 491576 reaction equation
C[O:2][C:3]([C:5]1[C:9]([C:10]([F:13])([F:12])[F:11])=[N:8][N:7]([CH3:14])[N:6]=1)=[O:4].[OH-].[K+]>C1COCC1>[CH3:14][N:7]1[N:6]=[C:5]([C:3]([OH:4])=[O:2])[C:9]([C:10]([F:13])([F:11])[F:12])=[N:8]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 67215212HCID 67215212, compound

Product 1

HCID 66849176HCID 66849176, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-methyl-5-trifluoromethyl-2H-1,2,3-triazole-4-carboxylic acid methyl ester [Compound Number 1.15] (2.09 g; 0.01 mol) and KOH (86%; 0.783 g; 1.2 eq.) in THF (50 ml) was heated at reflux temperature for 3.5 hours. The solution was evaporated, the residue was dissolved in water and acidified to pH 1-2 with HCl (1M). Evaporation of the aqueous solution followed by continuous extration in ethylacetate for 20 hours gave of Compound No 1.13 (2.11 g; 100%) as a crystalline solid.

Workup

  1. temperatureat reflux temperature for 3.5 hours
  2. customThe solution was evaporated
  3. dissolutionthe residue was dissolved in water
  4. customEvaporation of the aqueous solution
  5. customgave of Compound No 1.13 (2.11 g; 100%) as a crystalline solid

Sources & evidence

ORD record
ord-c97feed12f2247d89fd8362bac46c49e
Source dataset
uspto-grants-2009_05
Patent number
US07531559B2

Reaction notes

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