2-Chloro-5-nitroanisole → 2-Chloro-5-nitrophenol

HRID 491590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 491590
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11]C>CC(O)=O.Br>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11]

Komponenten

4

Edukt 1

HCID 705192-Chloro-5-nitroanisole

Produkt 1

HCID 692642-Chloro-5-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 260Hydrogen BromideLösungsmittel

Versuchsvorschrift

2-Chloro-5-nitroanisole (9.7 g, 49.1 mmol) in HOAc (78 mL) and 48% HBr (97 mL) was heated for 18 h at 140° C. The reaction was cooled to RT, diluted with ice water, and extracted with EtOAc once the ice had melted. The organic layer was brine-washed 4×, dried over Na2SO4, filtered, concentrated, and dried under vacuum to yield the title compound as yellow-light brown solid.

Aufarbeitung

  1. extractionextracted with EtOAc once the ice
  2. washwashed 4×
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e3d54c8fde044c86b06acf0bb34ff5e7
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07531553B2

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