反应详情

A flask was charged with 1-[-(5-nitro-2-pentafluoroethyl-phenoxy)-ethyl]-pyrrolidine (Step A) (1.8 g) and MeOH (25 mL) and placed under argon. Pd/C was added carefully and the atmosphere was replaced with H2. The reaction was stirred for 2.5 days at RT. The reaction mixture was blanketed with N2, filtered through a pad of Celite® and evaporated. The reaction mixture was taken up in a small amount of acetone, and filtered through a plug of silica gel using 90:10:1 (CH2Cl2:MeOH:NH4OH) as the eluant. The title compound was isolated as a yellow solid.

1. filtrationfiltered through a pad of Celite®
2. customevaporated
3. filtrationfiltered through a plug of silica gel using 90:10:1 (CH2Cl2:MeOH:NH4OH) as the eluant