1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → (4-chloro-3-trifluoromethyl-phenyl)-[6-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-1H-benzimidazol-2-yl]-amine
Reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][C:9]([O:10][C:11]3[CH:12]=[C:13]([NH2:18])[C:14]([NH2:17])=[CH:15][CH:16]=3)=[C:4]2[CH:3]=[CH:2]1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=S)=[CH:22][C:21]=1[C:29]([F:32])([F:31])[F:30]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]2[NH:18][C:13]3[CH:12]=[C:11]([O:10][C:9]4[CH:8]=[CH:7][N:6]=[C:5]5[NH:1][CH:2]=[CH:3][C:4]=45)[CH:16]=[CH:15][C:14]=3[N:17]=2)=[CH:22][C:21]=1[C:29]([F:30])([F:31])[F:32]Participants
3
Procedure
The title compound was prepared by the method described in Example 1, using 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzene-1,2-diamine (Step D, 0.082 g, 0.34 mmol) and 1-chloro-4-isothiocyanato-2-trifluoromethyl-benzene (0.081 g, 0.34 mmol). MS (MH+)=444.1, MW: 443.08 Calc'd for: C21H13ClF3N5O.
Sources & evidence
- ORD record
- ord-6cf2ef469ea64861ac289df648a1c119
- Source dataset
- uspto-grants-2009_05
- Patent number
- US07531553B2
Reaction notes
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