HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → (4-chloro-3-trifluoromethyl-phenyl)-[6-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-1H-benzimidazol-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene | HCID 520026 | — |
| Reactant | 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzene-1,2-diamine | HCID 17756494 | — |
| Product | (4-chloro-3-trifluoromethyl-phenyl)-[6-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-1H-benzimidazol-2-yl]-amine | HCID 17755115 | — |
Reaction Steps
The title compound was prepared by the method described in Example 1, using 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzene-1,2-diamine (Step D, 0.082 g, 0.34 mmol) and 1-chloro-4-isothiocyanato-2-trifluoromethyl-benzene (0.081 g, 0.34 mmol). MS (MH+)=444.1, MW: 443.08 Calc'd for: C21H13ClF3N5O.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531553B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-6cf2ef469ea64861ac289df648a1c119 |
| Source note | uspto-grants-2009_05 |