反应详情

4-(3,4-Dinitro-phenoxy)-quinoline (Step A, 400 mg, 1.2 mmol) was dissolved in THF at 0° C., and AcOH (1.5 mL) was added followed by zinc dust (2.5 g, 38 mmol). The mixture was stirred at RT for 1 h then filtered on a silica pad. The solvent was evaporated; the residue was dissolved in CH2Cl2 and washed with 1M NaOH. The organic phases were dried, filtered and evaporated to give the title compound, as a brown-orange oil.

1. filtrationthen filtered on a silica pad
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in CH2Cl2
4. washwashed with 1M NaOH
5. customThe organic phases were dried
6. filtrationfiltered
7. customevaporated