反应详情

2-Nitro-4-(quinolin-4-yloxy)-phenol (Step A, 200 mg) was dissolved in THF (50 mL) at 0° C. and AcOH (0.88 mL) was added followed by zinc dust (2.3 g). The mixture was stirred at RT for 1.5 h and filtered through a Celite® pad. The solvent was evaporated, the residue was dissolved in CH2Cl2 and washed with 1M NaOH. The organic phases were dried, filtered and evaporated to give the title compound as a brown solid.

1. filtrationfiltered through a Celite® pad
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in CH2Cl2
4. washwashed with 1M NaOH
5. customThe organic phases were dried
6. filtrationfiltered
7. customevaporated