HCID 17756595, compound → HCID 17755504, compound

HRID 491685Notes

Reaction equation

HRID 491685 reaction equation
C([O:8][C:9]1[CH:29]=[CH:28][C:12]([O:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][N:15]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[O:13][C:12]1[CH:28]=[CH:29][C:9]([OH:8])=[CH:10][CH:11]=1

Participants

3

Reactant 1

HCID 17756595HCID 17756595, compound

Product 1

HCID 17755504HCID 17755504, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

4-(4-Benzyloxy-phenoxy)-6,7-dimethoxyquinazoline (1.2 g) was heated at reflux with TFA (10 mL) for 20 h, and the mixture was concentrated in vacuo. The residue was diluted with water and basicified with NH4OH (conc.) and a solid precipitated. The solid as filtered, washed with water and Et2O and used directly in the next step. MS(MH+)=NA; Calc'd 298.30 for C16H14N2O4.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. additionThe residue was diluted with water
  3. customa solid precipitated
  4. filtrationThe solid as filtered
  5. washwashed with water and Et2O

Sources & evidence

ORD record
ord-11d9cc2b3a10488ab1ab6c64563d0db8
Source dataset
uspto-grants-2009_05
Patent number
US07531553B2

Reaction notes

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