反应详情

温度

20 °C

37.60 g (0.247 mol) of DBU are added dropwise to a suspension of 50.8 g (0.225 mol) of 2,2-diphenylpropionic acid and 200 ml of acetonitrile at 20° C. 70.10 g (0.494 mol) of methyliodide are added dropwise to the resulting solution within 30 min. Then the mixture is stirred overnight at 20° C. The solvent is evaporated down, the residue is extracted with diethylether/water, the organic phase is washed with water, dried over Na2SO4 and evaporated to dryness. Yield: 48.29 g of viscous residue 32 (=89% of theory).

1. customThe solvent is evaporated down
2. extractionthe residue is extracted with diethylether/water
3. washthe organic phase is washed with water
4. dry with materialdried over Na2SO4
5. customevaporated to dryness