反应详情

Into a warm (55° C.) mixture of Ag2O (13.5 g, 58.4 mmol), NaOH (19.5 g, 487 mmol) and water (200 mL) was added 2-fluoro-4-methoxybenzaldehyde (15 g, 97.4 mmol). The mixture was stirred for 1 h, filtered off and the precipitated solids were washed with hot water (10 mL). The filtrate was added slowly into cold (0° C.) HCl (5N) with vigorous stirring. The precipitated solid was filtered, washed with water and dried to give a white solid (13.6 g, 82% yield, m.p. 194-196° C.); MS m/e 169 (M−H)+.

1. temperatureInto a warm
2. filtrationfiltered off
3. washthe precipitated solids were washed with hot water (10 mL)
4. additionThe filtrate was added slowly into cold (0° C.) HCl (5N) with vigorous stirring
5. filtrationThe precipitated solid was filtered
6. washwashed with water
7. customdried