Hydrochloric Acid → 1-(4-Fluorophenyl)-4-methyl-2-oxoimidazolidine-4-carboxylic acid

Participants

Reaction Steps

A solution of 1-(4-fluoro-phenyl)-4-methyl-2-oxo-imidazolidine-4-carboxylic acid methyl ester (247 mg, 0.98 mmol) in methanol (15 mL) was treated with aqueous NaOH (1.50 mL, 6.38 mmol). After stirring 1 hour at room temperature, the mixture was treated with 1N HCl to pH 1 and the resulting white precipitate collected by filtration (135 mg, 58%).

Provenance & Evidence