Hydrochloric Acid → 1-(4-Fluorophenyl)-4-methyl-2-oxoimidazolidine-4-carboxylic acid

HRID 491764Notes

Reaction equation

HRID 491764 reaction equation
C[O:2][C:3]([C:5]1([CH3:18])[CH2:9][N:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[C:7](=[O:17])[NH:6]1)=[O:4].[OH-].[Na+].Cl>CO>[F:16][C:13]1[CH:12]=[CH:11][C:10]([N:8]2[CH2:9][C:5]([CH3:18])([C:3]([OH:4])=[O:2])[NH:6][C:7]2=[O:17])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 441926211-(4-Fluoro-phenyl)-4-methyl-2-oxo-imidazolidine-4-carboxylic acid methyl ester

Product 1

HCID 441926221-(4-Fluorophenyl)-4-methyl-2-oxoimidazolidine-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(4-fluoro-phenyl)-4-methyl-2-oxo-imidazolidine-4-carboxylic acid methyl ester (247 mg, 0.98 mmol) in methanol (15 mL) was treated with aqueous NaOH (1.50 mL, 6.38 mmol). After stirring 1 hour at room temperature, the mixture was treated with 1N HCl to pH 1 and the resulting white precipitate collected by filtration (135 mg, 58%).

Workup

  1. filtrationthe resulting white precipitate collected by filtration (135 mg, 58%)

Sources & evidence

ORD record
ord-b41cb0b49e4e466b9bbcd2b57bd6a2ca
Source dataset
uspto-grants-2009_05
Patent number
US07531565B2

Reaction notes

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