HCID 53904438, compound → Tropenol 2-fluoro-2,2-diphenylacetate

HRID 49177Notes

Reaction equation

HRID 49177 reaction equation
COCCS(F)(F)([F:11])(CCOC)N.[C:14]([O:30][C@@:31]12[N:38]([CH3:39])[C@@H:35]([CH2:36][CH2:37]1)[CH2:34][CH:33]=[CH:32]2)(=[O:29])[C:15]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)O>C(Cl)(Cl)Cl>[C@@:31]12([OH:30])[N:38]([CH3:39])[C@@H:35]([CH2:36][CH2:37]1)[CH2:34][CH:33]=[CH:32]2.[F:11][C:15]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14]([O-:30])=[O:29]

Participants

4

Reactant 2

HCID 53904438HCID 53904438, compoundHCID 86585680Tropenol benzilate

Product 1

HCID 86585679Tropenol 2-fluoro-2,2-diphenylacetate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

15.86 ml (0.086 mol) of bis-(2-methoxyethyl)-aminosulphur trifluoride are reacted with 25 g (0.072 mol) of 5f analogously to Example 4, step 4.3 in 480 ml of chloroform. The product is recrystallised from acetone in the form of its hydrochloride. Yield: 18.6 g of white crystals (=67% of theory);

Workup

  1. customThe product is recrystallised from acetone in the form of its hydrochloride

Sources & evidence

ORD record
ord-ab215f0c7cc14b3b9dc804990fbbf00b
Source dataset
uspto-grants-2004_03
Patent number
US06706726B2

Reaction notes

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