Isopropanol → HCID 178484077, compound

Participants

Reaction Steps

Trans-5-t-butoxycarbonylmethoxy-3-[4-(dimethylamino)-cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (1.92 g) obtained in Example 31 is dissolved in 6N hydrochloric acid (40 ml), and the mixture is stirred at room temperature for 2 hours. To the reaction solution is added isopropanol (100 ml), and the precipitated solid is collected by filtration, washed with isopropanol and diethyl ether, and dried under reduced pressure to give the title compound (1.86 g).

Provenance & Evidence