Isopropanol → HCID 178484077, compound

HRID 491773Notes

Reaction equation

HRID 491773 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][C:16]([C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][N:22]=3)=[O:19])=[C:15]([NH:28][C:29]([C@H:31]3[CH2:36][CH2:35][C@H:34]([N:37]([CH3:39])[CH3:38])[CH2:33][CH2:32]3)=[O:30])[C:14]=2[CH:40]=1)=[O:7])(C)(C)C.C(O)(C)C>Cl>[ClH:27].[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][C:16]([C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][N:22]=3)=[O:19])=[C:15]([NH:28][C:29]([C@H:31]3[CH2:36][CH2:35][C@H:34]([N:37]([CH3:38])[CH3:39])[CH2:33][CH2:32]3)=[O:30])[C:14]=2[CH:40]=1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 178484078HCID 178484078, compound

Product 1

HCID 178484077HCID 178484077, compoundYield 200.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Trans-5-t-butoxycarbonylmethoxy-3-[4-(dimethylamino)-cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (1.92 g) obtained in Example 31 is dissolved in 6N hydrochloric acid (40 ml), and the mixture is stirred at room temperature for 2 hours. To the reaction solution is added isopropanol (100 ml), and the precipitated solid is collected by filtration, washed with isopropanol and diethyl ether, and dried under reduced pressure to give the title compound (1.86 g).

Workup

  1. filtrationthe precipitated solid is collected by filtration
  2. washwashed with isopropanol and diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-3901d0f3171e4c4da45d5032046004f5
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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