Hydrochloric Acid → HCID 178484423, compound

Participants

Reaction Steps

Trans-5-[2-(N-t-butoxycarbonyl-N-methylamino)ethoxy]-3-[4-(dimethylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (300 mg) obtained in Example 36 is dissolved in dioxane (5 ml), and thereto is added 4N hydrogen chloride in dioxane (10 ml), and the mixture stirred at room temperature for 5 hours. The reaction solution is concentrated under reduced pressure, and the resulting residue is suspended in diethyl ether. The precipitates are collected by filtration, and dried to give the title compound (301 mg).

Provenance & Evidence