Hydrochloric Acid → HCID 178484423, compound

HRID 491776Notes

Reaction equation

HRID 491776 reaction equation
C(O[C:6]([N:8]([CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]2[O:20][C:19]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][N:25]=3)=[O:22])=[C:18]([NH:31][C:32]([C@H:34]3[CH2:39][CH2:38][C@H:37]([N:40]([CH3:42])[CH3:41])[CH2:36][CH2:35]3)=[O:33])[C:17]=2[CH:43]=1)C)=O)(C)(C)C.[ClH:44]>O1CCOCC1>[ClH:30].[ClH:44].[ClH:30].[CH3:42][N:40]([CH3:41])[C@H:37]1[CH2:38][CH2:39][C@H:34]([C:32]([NH:31][C:18]2[C:17]3[CH:43]=[C:13]([O:12][CH2:11][CH2:10][NH:8][CH3:6])[CH:14]=[CH:15][C:16]=3[O:20][C:19]=2[C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][N:25]=2)=[O:22])=[O:33])[CH2:35][CH2:36]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178484424HCID 178484424, compound

Product 1

HCID 178484423HCID 178484423, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Trans-5-[2-(N-t-butoxycarbonyl-N-methylamino)ethoxy]-3-[4-(dimethylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (300 mg) obtained in Example 36 is dissolved in dioxane (5 ml), and thereto is added 4N hydrogen chloride in dioxane (10 ml), and the mixture stirred at room temperature for 5 hours. The reaction solution is concentrated under reduced pressure, and the resulting residue is suspended in diethyl ether. The precipitates are collected by filtration, and dried to give the title compound (301 mg).

Workup

  1. concentrationThe reaction solution is concentrated under reduced pressure
  2. filtrationThe precipitates are collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-f6eaaf882f0940fe857a0e69e246fc82
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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