Hydrochloric Acid → HCID 178484810, compound

HRID 491781Notes

Reaction equation

HRID 491781 reaction equation
C(O[C:6]([N:8]([C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([NH:18][C:19]2[C:23]3[CH:24]=[C:25]([C:28]([O:30][CH3:31])=[O:29])[CH:26]=[CH:27][C:22]=3[O:21][C:20]=2[C:32]([NH:34][C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][N:36]=2)=[O:33])=[O:17])[CH2:12][CH2:11]1)C)=O)(C)(C)C.Cl>O1CCOCC1.C(OCC)C>[ClH:41].[CH3:31][O:30][C:28]([C:25]1[CH:26]=[CH:27][C:22]2[O:21][C:20]([C:32]([NH:34][C:35]3[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][N:36]=3)=[O:33])=[C:19]([NH:18][C:16]([C@H:13]3[CH2:12][CH2:11][C@H:10]([NH:8][CH3:6])[CH2:15][CH2:14]3)=[O:17])[C:23]=2[CH:24]=1)=[O:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178497420HCID 178497420, compound

Product 1

HCID 178484810HCID 178484810, compoundYield 196.1%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

Trans-3-[4-(N-t-butoxycarbonyl-N-methylamino)cyclohexylcarbonylamino]-5-methoxycarbonyl-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (4.60 g) obtained in Example 202 is dissolved in dioxane (20 ml), and thereto is added 4N hydrogen chloride in dioxane (10 ml), and the mixture is stirred at room temperature for 48 hours. The reaction solution is diluted with diethyl ether, and the precipitates are collected by filtration, washed several times with diethyl ether and dried to give the title compound (4.02 g).

Workup

  1. filtrationthe precipitates are collected by filtration
  2. washwashed several times with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-f7a6f507f8e642b993af44d4e7821d9e
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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