Hydrochloric Acid → HCID 178478721, compound

HRID 491782Notes

Reaction equation

HRID 491782 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([NH:17][C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][C:19]=2[C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][N:31]=2)=[O:28])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:37]>O1CCOCC1>[ClH:36].[ClH:37].[NH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([NH:17][C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][C:19]=2[C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][N:31]=2)=[O:28])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453967HCID 178453967, compound

Product 1

HCID 178478721HCID 178478721, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Trans-3-[4-(t-butoxycarbonylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (10.70 g) obtained in Example 203 is dissolved in dioxane (150 ml), and thereto is added 4N hydrogen chloride in dioxane (150 ml). The mixture is stirred at room temperature for 12 hours, and concentrated under reduced pressure. The residue is crushed in diethyl ether, and collected by filtration to give the title compound (9.80 g).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue is crushed in diethyl ether
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-360b3445503a461e8a0d137fda033051
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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