反应详情

Trans-3-[4-(t-butoxycarbonylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (10.70 g) obtained in Example 203 is dissolved in dioxane (150 ml), and thereto is added 4N hydrogen chloride in dioxane (150 ml). The mixture is stirred at room temperature for 12 hours, and concentrated under reduced pressure. The residue is crushed in diethyl ether, and collected by filtration to give the title compound (9.80 g).

1. concentrationconcentrated under reduced pressure
2. customThe residue is crushed in diethyl ether
3. filtrationcollected by filtration