Methyl iodide → HCID 86602241, compound

HRID 491801Notes

Reaction equation

HRID 491801 reaction equation
[CH3:1][N:2]([CH3:31])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([NH:11][C:12]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[O:14][C:13]=2[C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)=[O:22])=[O:10])[CH2:5][CH2:4]1.[CH3:32][I:33]>ClCCl>[I-:33].[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:21]([C:13]2[O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:12]=2[NH:11][C:9]([CH:6]2[CH2:7][CH2:8][CH:3]([N+:2]([CH3:32])([CH3:31])[CH3:1])[CH2:4][CH2:5]2)=[O:10])=[O:22])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178484068HCID 178484068, compound

Product 1

HCID 86602241HCID 86602241, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trans-3-[4-(dimethylamino)cyclohexylcarbonylamino]-N-(4-chlorophenyl)benzofuran-2-carboxamide (106 mg) obtained in Example 308 is dissolved in dichloromethane (5 ml), and thereto is added methyl iodide (30 μl), and the mixture is stirred at room temperature for 5 hours. To the reaction solution is poured dichloromethane diethyl ether (1/5, 25 ml), and the precipitates are collected by filtration to give the title compound (126 mg).

Workup

  1. filtrationthe precipitates are collected by filtration

Sources & evidence

ORD record
ord-75232afa903f4d818ae1be21126c5745
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

Loading…