反应详情

A solution of 4-{(2-benzyloxy-ethyl)-[4-tert-butoxycarbonylamino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-amino}-cis-cyclohexanecarboxylic acid benzyl ester (4.8 g, 7.5 mmol) in TFA (5% in CH2Cl2, 100 mL) was stirred at room temperature overnight. The solvent and most of the TFA was evaporated, and EtOAc (300 mL) was added to the residue. The solution was washed with aq. NaHCO3 and aq. NaCl. The organic layer was dried with MgSO4 and evaporated to yield 4-[[4-amino-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid benzyl ester as a light brown oil.

1. customThe solvent and most of the TFA was evaporated
2. additionEtOAc (300 mL) was added to the residue
3. washThe solution was washed with aq. NaHCO3 and aq. NaCl
4. dry with materialThe organic layer was dried with MgSO4
5. customevaporated