反应详情

A mixture of 0.23 grams (0.688 mmoles) N-(5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-3-fluoro-benzenesulfonamide, 0.15 mL 6M hydrochloric acid, and 0.112 grams (1.38 mmole) potassium cyanate in 25 mL water was heated under reflux for 1.5 hours. The solid precipitate was collected by filtration and dried in vacuo to provide 3-fluoro-N-(5-ureidomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide as a white solid, 0.21 gram (81%), m.p. 162-163° C., M+H=378.

1. temperaturewas heated
2. temperatureunder reflux for 1.5 hours
3. filtrationThe solid precipitate was collected by filtration
4. customdried in vacuo