Oxalyl chloride → HCID 86596415, compound

Participants

Reaction Conditions

Reaction Steps

0.7 cm3 (8 mmol) of oxalyl chloride is added to a suspension, cooled to a temperature in the region of 5° C., of 0.74 g (2.57 mmol) of 3-carboxy-1-(isoquinol-3-yl)-1H-indole in 15 cm3 of dichloromethane under an argon atmosphere. After stirring at a temperature in the region of 22° C. for 15 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue, dissolved in 15 cm3 of dichloromethane, is again reacted with 1 cm3 (11.46 mmol) of oxalyl chloride. After stirring at a temperature in the region of 22° C. for 48 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give 0.7 g of 3-chlorocarbonyl-1-(isoquinol-3-yl)-1H-indole hydrochloride in the form of a yellow solid which is used directly in the following step.

Provenance & Evidence