反应详情

温度

22 °C

0.7 cm3 (8 mmol) of oxalyl chloride is added to a suspension, cooled to a temperature in the region of 5° C., of 0.74 g (2.57 mmol) of 3-carboxy-1-(isoquinol-3-yl)-1H-indole in 15 cm3 of dichloromethane under an argon atmosphere. After stirring at a temperature in the region of 22° C. for 15 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). The residue, dissolved in 15 cm3 of dichloromethane, is again reacted with 1 cm3 (11.46 mmol) of oxalyl chloride. After stirring at a temperature in the region of 22° C. for 48 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give 0.7 g of 3-chlorocarbonyl-1-(isoquinol-3-yl)-1H-indole hydrochloride in the form of a yellow solid which is used directly in the following step.

1. concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)
2. dissolutionThe residue, dissolved in 15 cm3 of dichloromethane
3. stirringAfter stirring at a temperature in the region of 22° C. for 48 hours
4. concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)