Hydrochloric Acid → HCID 178446408, compound

Participants

Reaction Steps

N-[[[(2,6-Diisopropylphenyl)amino]carbonyl]methyl]-N-pentyl-N-[[2′-[N-(triphenylmethyl)tetrazol-5-yl]-1,1′-biphenyl-4-yl]methyl]amine (278.3 mg) was dissolved in tetrahydrofuran (10 mL), and after addition of 10% hydrochloric acid (3.0 mL), the resulting mixture was stirred at room temperature. Nineteen hours later, the solvent was distilled off, and to the residue, water (30 mL) was added. The mixture so obtained was extracted twice with chloroform (30 mL, each). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was subjected to chromatography on a silica gel column (chloroform/methanol) to afford N-[[[(2,6-diisopropylphenyl) amino]carbonyl]methyl]-N-pentyl-N-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]amine hydrochloride as pale yellow crystals (190.6 mg). Yield: 93%.

Provenance & Evidence