反应详情

4-(Piperidin-1-yl)piperidine-1-carboxylic acid [4-(4-nitrophenoxy)pyridin-2-yl]amide (121 mg) was dissolved in tetrahydrofuran (3 ml)-methanol (3 ml), and then 10% palladium carbon (61 mg) was added thereto under a nitrogen atmosphere, followed by replacing with hydrogen inside the system and stirring overnight. After replacing with nitrogen inside the system, the reaction mixture was filtered to remove the catalyst, which was washed with ethanol. The filtrate was concentrated under a reduced pressure to give a residue, which was then suspended in diethyl ether (2 ml)-hexane (2 ml). The solid was filtered off and dried under aeration to provide the titled compound (84.8 mg, 75.2%).

1. filtrationthe reaction mixture was filtered
2. customto remove the catalyst, which
3. washwas washed with ethanol
4. concentrationThe filtrate was concentrated under a reduced pressure
5. customto give a residue, which
6. filtrationThe solid was filtered off
7. customdried under aeration