Water → 4-(Dimethylamino)piperidine dihydrochloride

After adding 10% palladium-carbon (2.0 g) to a solution of the crude 4-dimethylamino-1-benzylpiperidine dihydrochloride (30.0 g) in 2-propanol (300 ml)-water (300 ml), the mixture was stirred for 22 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered and washed with 2-propanol. The filtrate was then concentrated. The obtained crystals were suspended in ethanol (50 ml). They were then diluted with diethyl ether (50 ml). The crystals were subsequently filtered and washed with methanol (10 ml). They were then subjected to aeration drying to provide the title compound (16.4 g) as colorless crystals.

1. filtrationThe catalyst was filtered
2. washwashed with 2-propanol
3. concentrationThe filtrate was then concentrated
4. additionThey were then diluted with diethyl ether (50 ml)
5. filtrationThe crystals were subsequently filtered
6. washwashed with methanol (10 ml)
7. customdrying

ORD record

ord-21c5d9ace9af48b4810dd4b2b2cac66e

Source dataset

uspto-grants-2009_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07531532B2