HCID 57677675, compound → HCID 86602168, compound

HRID 492865Notes

Reaction equation

HRID 492865 reaction equation
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8]([C:11]([NH:13][C:14]3[CH:19]=[C:18]([O:20][C:21]4[CH:26]=[CH:25][C:24]([NH:27]C(=O)OCC5C=CC=CC=5)=[C:23]([F:38])[CH:22]=4)[CH:17]=[CH:16][N:15]=3)=[O:12])[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1>O1CCCC1.[C].[Pd]>[NH2:27][C:24]1[CH:25]=[CH:26][C:21]([O:20][C:18]2[CH:17]=[CH:16][N:15]=[C:14]([NH:13][C:11]([N:8]3[CH2:9][CH2:10][CH:5]([N:1]4[CH2:4][CH2:3][CH2:2]4)[CH2:6][CH2:7]3)=[O:12])[CH:19]=2)=[CH:22][C:23]=1[F:38]

Participants

4

Reactant 1

HCID 57677675HCID 57677675, compound

Product 1

HCID 86602168HCID 86602168, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

After adding 10% palladium-carbon (26.2 mg) to a solution of benzyl [4-(2-{[4-(azetidin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yloxy)-2-fluorophenyl]carbamate (128 mg) in tetrahydrofuran (10 ml), the mixture was stirred for 16 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered and washed with tetrahydrofuran (4 ml) to provide a solution of 4-(azetidin-1-yl)piperidine-1-carboxylic acid [4-(4-amino-3-fluorophenoxy)pyridin-2-yl]amide in tetrahydrofuran (approximately 14 ml)

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with tetrahydrofuran (4 ml)

Sources & evidence

ORD record
ord-a3a3e63438fe4cedb4bcfd622e4a7f87
Source dataset
uspto-grants-2009_05
Patent number
US07531532B2

Reaction notes

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