反应详情

After adding 10% palladium-carbon (5.0 g) to a solution of the crude N-[1-(1-benzylpiperidin-4-yl)azetidin-3-yl]-N,N-dimethylamine trihydrochloride (14.1 g) in 2-propanol (380 ml)-water (380 ml), the mixture was stirred for 12 hours at room temperature under a hydrogen atmosphere. The catalyst was then filtered. The filtrate was concentrated under reduced pressure to provide a crude product of the title compound (10.7 g) as colorless crystals.

1. filtrationThe catalyst was then filtered
2. concentrationThe filtrate was concentrated under reduced pressure