Water → HCID 57677543, compound

Temperature

100 °C

Lithium aluminum hydride (2.98 g) was gradually added to a solution of tert-butyl (3-azetidin-1-yl-3-oxopropyl)carbamate (5.99 g) in tetrahydrofuran (150 ml) while stirring in an ice bath. The mixture was stirred under a nitrogen atmosphere, for 15 minutes in an ice bath and for 45 minutes at room temperature. It was then heated and stirred for 8 hours at 80° C. under a nitrogen atmosphere. The reaction mixture was further heated to reflux for 34 hours at 100° C. under a nitrogen atmosphere. It was then cooled in an ice bath. Water (2.98 ml), 5N aqueous sodium hydroxide (2.98 ml) and water (8.94 ml) were added thereto in that order while stirring, and the mixture was stirred at room temperature for 3 days. The insoluble portion was then filtered. The filtrate was concentrated under reduced pressure to provide the title compound (2.78 g, 82.8%) as a brown oil.

1. stirringThe mixture was stirred under a nitrogen atmosphere, for 15 minutes in an ice bath and for 45 minutes at room temperature
2. temperatureIt was then heated
3. stirringstirred for 8 hours at 80° C. under a nitrogen atmosphere
4. temperatureThe reaction mixture was further heated
5. temperatureIt was then cooled in an ice bath
6. stirringin that order while stirring
7. stirringthe mixture was stirred at room temperature for 3 days
8. filtrationThe insoluble portion was then filtered
9. concentrationThe filtrate was concentrated under reduced pressure

ORD record

ord-278215be3f9a494f89c2329d5068e645

Source dataset

uspto-grants-2009_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07531532B2