反应详情

To a solution of 1,4-bis[5-(2,3-dimethoxyphenyl)-2-pyridyl]hexahydro-1,4-diazepine (28.0 mg, 0.053 mmol) in chloroform (3.0 mL) was added a 1.0 M solution of methane-sulfonic acid in methanol (0.11 mL, 0.11 mmol), and the reaction mixture was concentrated under reduced pressure. The residue was recrystallized from methylene chloride-methanol-diethyl ether to yield the title compound as a pale brown crystalline powder (melting point: 199.5-202.0° C.) (32.3 mg, yield: 86%).

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customThe residue was recrystallized from methylene chloride-methanol-diethyl ether