Hydrochloric Acid → HCID 20634947, compound

HRID 49297Notes

Reaction equation

HRID 49297 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6]([C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([C:26]4[CH:31]=[CH:30][C:29]([C:32]5[CH:37]=[C:36]([CH2:38][O:39][CH3:40])[CH:35]=[C:34]([CH2:41][O:42][CH3:43])[CH:33]=5)=[CH:28][N:27]=4)[CH2:21][CH2:20]3)=[N:17][CH:18]=2)[CH:7]=[C:8]([CH2:10][O:11][CH3:12])[CH:9]=1.[ClH:44]>C(O)C>[ClH:44].[ClH:44].[CH3:43][O:42][CH2:41][C:34]1[CH:33]=[C:32]([C:29]2[CH:30]=[CH:31][C:26]([N:22]3[CH2:23][CH2:24][CH2:25][N:19]([C:16]4[CH:15]=[CH:14][C:13]([C:6]5[CH:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:9]=[C:8]([CH2:10][O:11][CH3:12])[CH:7]=5)=[CH:18][N:17]=4)[CH2:20][CH2:21]3)=[N:27][CH:28]=2)[CH:37]=[C:36]([CH2:38][O:39][CH3:40])[CH:35]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20634946HCID 20634946, compound

Product 1

HCID 20634947HCID 20634947, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1,4-bis[5-[3,5-bis(methoxymethyl)phenyl]-2-pyridyl]hexahydro-1,4-diazepine (51.9 mg, 0.0892 mmol) in ethanol (5.0 mL) was added 1.0 M hydrochloric acid (0.21 mL, 0.21 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue and the resulting mixture was concentrated under reduced pressure to yield the title compound as a colorless amorphous powder (47.8 mg, yield: 92%).

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. additionEthanol (5.0 mL) was added to the residue
  3. concentrationthe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c7104f42f20647f39f5a7a0b544cfeca
Source dataset
uspto-grants-2004_03
Patent number
US06706703B2

Reaction notes

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