Water → 2,4-dihydro-5-methyl-2-(2-pyridinyl)-3H-Pyrazol-3-one

HRID 493009Notes

Reaction equation

HRID 493009 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[NH2:2].[OH2:9]>C(O)(=O)C>[CH3:5][C:6]1[CH2:7][C:8](=[O:9])[N:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)[N:2]=1

Participants

4

Reactant 2

HCID 962WaterHCID 786452-Hydrazinopyridine

Product 1

HCID 6676522,4-dihydro-5-methyl-2-(2-pyridinyl)-3H-Pyrazol-3-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.5 g (4.44 mmol) of 2-hydrazinopyridine and 0.58 g (4.44 mmol) of acetoacetic ester are stirred in 15 ml of glacial acetic acid for 2 hours at 90° C. The mixture is then diluted with water and the precipitated crystals are filtered off with suction, washed again with water and dried under reduced pressure.

Workup

  1. filtrationthe precipitated crystals are filtered off with suction
  2. washwashed again with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-8c446801a3314768959151221694d75e
Source dataset
uspto-grants-2009_05
Patent number
US07534273B2

Reaction notes

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