4-(Dimethylamino)Benzaldehyde → HCID 68826834, compound

HRID 493012Notes

Reaction equation

HRID 493012 reaction equation
[CH3:1][C:2]1[CH2:3][C:4](=[O:13])[N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[N:6]=1.[CH3:14][N:15]([CH3:24])[C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1.N1CCCCC1>C(O)C.O>[CH3:14][N:15]([CH3:24])[C:16]1[CH:23]=[CH:22][C:19](/[CH:20]=[C:3]2/[C:4](=[O:13])[N:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)[N:6]=[C:2]/2[CH3:1])=[CH:18][CH:17]=1

Participants

6

Reactant 3

HCID 74794-(Dimethylamino)BenzaldehydeHCID 8082PiperidineHCID 6676522,4-dihydro-5-methyl-2-(2-pyridinyl)-3H-Pyrazol-3-one

Product 1

HCID 68826834HCID 68826834, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1.3 g (7.42 mmol) of 5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one and 1.68 g (11.13 mmol) of 4-(dimethylamino)benzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the orange-red precipitate is filtered off, then washed with water and dried under reduced pressure.

Workup

  1. filtrationthe orange-red precipitate is filtered off
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-92895b2d68494fc5929d0a587bc09cac
Source dataset
uspto-grants-2009_05
Patent number
US07534273B2

Reaction notes

Loading…