反应详情

The reaction was carried out in the same manner as in the step (i), except for using 4-n-propylphenylacetylene synthesized in the step (ii) and 1-(tert-butoxycarbonyloxy)-4-bromobenzene synthesized in the Example 4 instead of 1-n-propyl-4-bromobenzene and trimethylsilylacetylene, respectively. After completion of the reaction, the reaction solution was poured into an iced water, and the resultant solution was acidified by adding hydrochloric acid. After the resultant solid was collected by filtration, the collected solid was washed with water, dried, and recrystallized successively from hexane and ethanol to provide 4.1 g (12.1 mmol) of 1-[4-(tert-butoxycarbonyloxy)phenyl]-2-(4-n-propylphenyl)acetylene.

1. customAfter completion of the reaction
2. filtrationAfter the resultant solid was collected by filtration
3. washthe collected solid was washed with water
4. customdried
5. customrecrystallized successively from hexane and ethanol