反应详情

To a stirred solution of compound 12 (201 mg, 0.4 mmol) in anhydrous CH2Cl2 (10 mL) was added hydrofluoric acid (48%, 6 mL). After 40 minutes of stirring at room temperature, water was added, and the organic layer was separated, washed with water and NaHCO3, dried over MgSO4, and evaporated. The residue was chromatographed on silica Sep-Pak cartridge using hexane/EtOAc (6:4) as an eluent to give an oily diol 13 (76.4 mg, 92%).

1. customthe organic layer was separated
2. washwashed with water and NaHCO3
3. dry with materialdried over MgSO4
4. customevaporated
5. customThe residue was chromatographed on silica Sep-Pak cartridge