反应详情

To a solution of diol 13 (55 mg, 0.27 mmol) in ethyl acetate (10 mL) was added Pd/C (10%, 50 mg). The reaction mixture was stirred for 18 hours under a continuous stream of hydrogen at room temperature. The mixture was then filtered, and the solvent was evaporated under reduced pressure. The crude oily product was chromatographed on silica Sep-Pak cartridge eluted with hexane/EtOAc (8:2) to give an oily diol 14 (55 mg, 45%).

1. filtrationThe mixture was then filtered
2. customthe solvent was evaporated under reduced pressure
3. customThe crude oily product was chromatographed on silica Sep-Pak cartridge
4. washeluted with hexane/EtOAc (8:2)