反应详情

To a solution of 1,4-bis[5-(4-acetyl-3,5-dimethoxyphenyl)-2-pyridyl]hexahydro-1,4-diazepine (80.0 mg, 0.130 mmol) in chloroform (5.0 mL), a 1.0 M solution of methanesulfonic acid in methanol (0.33 mL, 0.33 mmol) was added, and the reaction mixture was concentrated under reduced pressure. The residue was recrystallized from methanol-diethyl ether to yield the title compound as a colorless crystalline powder (melting point: 236.0-238.0° C.) (94.8 mg, yield: 90%).

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customThe residue was recrystallized from methanol-diethyl ether