反应详情

1 mL H2SO4 is added to 2-bromo-5-methyl-benzoic acid (7.5 g, 70 mmol) in 75 mL methanol. The reaction mixture is refluxed 16 hours and cooled to room temperature. 100 mL saturated NaHCO3 (aq) is added. Methanol is removed in vacuo. The resulting mixture is extracted with ethyl acetate. The organic phase is washed with brine, dried with MgSO4 and concentrated in vacuo to give the title compound.

1. temperatureThe reaction mixture is refluxed 16 hours
2. customMethanol is removed in vacuo
3. extractionThe resulting mixture is extracted with ethyl acetate
4. washThe organic phase is washed with brine
5. dry with materialdried with MgSO4
6. concentrationconcentrated in vacuo