反应详情

A solution of the product of Step 2 (337 mg, 1.29 mmol) in glacial acetic acid (4 mL) in a sealed tube was heated at 120° C. for 60 h. The solvent was evaporated under reduced pressure, and the resulting residue purified by preparative HPLC to give the product (52 mg). MS m/e 417; HPLC retention time 3.44 min.

1. customThe solvent was evaporated under reduced pressure
2. customthe resulting residue purified by preparative HPLC