3-Hydroxy-4-(3-(4-pentylphenylsulfonamido)propanamido)benzoic acid → 2-(2-(4-Pentylphenylsulfonamido)ethyl)benzo[d] oxazole-6-carboxylic acid

Participants

Reaction Steps

A solution of the product of Step 2 (337 mg, 1.29 mmol) in glacial acetic acid (4 mL) in a sealed tube was heated at 120° C. for 60 h. The solvent was evaporated under reduced pressure, and the resulting residue purified by preparative HPLC to give the product (52 mg). MS m/e 417; HPLC retention time 3.44 min.

Provenance & Evidence