反应详情

The above prepared 6-(1-isopropyl-piperidin-4-yloxy)-benzo[b]thiophene-2-carboxylic acid ethyl ester (0.359 g, 1.033 mmol) was dissolved in 2 mL of THF/ethanol=1/1 and treated with 0.517 mL of aq. NaOH (3M, 1.5 eq.). The mixture was stirred for 1 h at ambient temperature and was then neutralized by adding 0.77 mL of 2M HCl (1.5 eq.). Careful evaporation of all solvents and drying afforded then 0.475 g of the title compound as white solid contaminated with innocouos inorganic salts.

1. customCareful evaporation of all solvents
2. customdrying
3. customafforded