反应详情

To a stirred solution of ethyl 1-phenylsulfonylindole-2-carboxylate (1 eq.) in DMF (2.5 ml/mmol) under N2, was added a solution of bromine (4 eq.) in DMF (0.5 ml/mmol). This reaction mixture was stirred at room temperature for about 4 hours, following which water was added and the mixture was extracted with dichloromethane (×3). The organic layer was washed with a saturated solution of Na2SO5, dried and evaporated to give a crude yellow oil. Purification by chromatography on silica gel (eluent: C6H12/EtOAc 9/1) afforded 3-brominated indole 11.

1. additionwas added
2. extractionthe mixture was extracted with dichloromethane (×3)
3. washThe organic layer was washed with a saturated solution of Na2SO5
4. customdried
5. customevaporated
6. customto give a crude yellow oil
7. customPurification by chromatography on silica gel (eluent: C6H12/EtOAc 9/1)