2-Methylpiperazine → HCID 22036410, compound

HRID 493269Notes

Reaction equation

HRID 493269 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:19][CH:20]1[CH2:25][NH:24][CH2:23][CH2:22][NH:21]1>>[CH3:19][CH:20]1[NH:21][CH2:22][CH2:23][N:24]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:25]1

Participants

3

Reactant 2

HCID 660572-MethylpiperazineHCID 22036540HCID 22036540, compound

Product 1

HCID 22036410HCID 22036410, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and 2-methylpiperazine (256 mg, 2.56 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 143 mg (77%) of the title product. HRMS m/z calcd for C17H21ClN4O2 (M)+ 348.1353, found 348.1370. Anal. (C17H21ClN4O2) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-498f22beb9c343faac30eaa8d0d35e62
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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